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| Living TumorTM xenograft models are developed using human tumor tissues grafted in subrenal capsules of SCID mice. The human tumor tissues are developed into transplantable tumor tissue lines. These tumor tissue lines offer a sustainable tumor source for xenograft models. The model is in many aspects superior to conventional tumor model systems which are based on cultured cancer cell lines. |
| Features |
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Resemblance to human tumor: At the subrenal capsule graft site, the Living TumorTM tissue lines retain the cell heterogeneity of the original human cancer and better retain original drug sensitivities, genotype and phenotype.
Predictable metastasis: Living TumorTM tissue lines metastasize predictably and retain the original human tumor phenotype.
Wide spectrum of tumor stages: Living TumorTM tissue lines represent different cancer types and a wide spectrum of early to late stage cancers. |
| Applications |
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Tumor growth inhibition studies
Orthotopic models for tumor metastatic studies
Tumor models for classes of therapeutic agents
Maximum tolerated dose, acute and subacute toxicity
Histopathology, Immunohistochemistry, In Situ Hybridization and qRT-PCR analysis |
| Description |
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Patient tissue will be collected and cut into small pieces. Small tissue samples will be implanted into the subrenal capsule of the mouse. The tissue will grow and be ready for following generations of xenografting. After a few generations of grafting, a Living Tumor TM line will be established.
Biochain will establish tumor lines by the fresh tumor tissues provided by customers or tissues procured by us under customers' request. It will take 6-10 months to generate a new grafted tumor line successfully. DNA/RNA/Protein lysate/Tissue Sections of the custom made tumor lines can be offered separately.
Please contact us for more details. |
General Animal Services
